Pharma Focus Asia

Effects Of Particle Size On The Triboelectrification Phenomenon In Pharmaceutical Excipients: An Experimental Case Study


Particle sizes play a major role to mediate charge transfer, both between identical and different material surfaces. The study probes in to the probable mechanism that actuates opposite polarities between two different size fractions of the same material by analyzing the charge transfer patterns of two different sizes of MCC. Quantum scale calculations confirmed alteration of charge transfer capacities due to variation of moisture content predicted by multiple surface and bulk analytical techniques. Discrete Element Method (DEM) based multi-scale computational models pertinent to predict charge transfer capacities were further implemented, and the results were in accordance to the experimental charge profiles. 

Tribocharging refers to the phenomenon of charging two solid surfaces when they are brought into contact and separated, acquiring positive or negative polarities based on the mechanisms of charge transfer. The hazards and problems related to tribocharging have been long known, and reports of related instances can be dated back to as early as 1745, when jets of water from an electrostatic machine led to the ignition of Spritius Frobenii (a sulphuric ether). 

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